Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Zhimin Luo; Wujin Sun; Jun Fang; KangJu Lee; Song Li; Zhen Gu; Mehmet R Dokmeci; Ali Khademhosseini

doi:10.1002/adhm.201801054

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Adv Healthc Mater. 2019 Feb;8(3):e1801054. doi: 10.1002/adhm.201801054. Epub 2018 Dec 19.

Authors

Zhimin Luo^{1

2

3

4}, Wujin Sun^{1

3}, Jun Fang¹, KangJu Lee^{1

3}, Song Li^{1

5}, Zhen Gu^{1

3

6}, Mehmet R Dokmeci^{1

3

7}, Ali Khademhosseini^{1

3

7

6

8

9}

Affiliations

¹ Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
² School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.
³ Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California-Los Angleles, Los Angeles, CA, 90095, USA.
⁴ Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810001, China.
⁵ Department of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁶ Jonsson Comprehensive Cancer Center, University of California - Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90024, USA.
⁷ Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁸ Department of Radiology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁹ Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143701, Republic of Korea.

Abstract

Biocompatible and bioresponsive microneedles (MNs) are emerging technology platforms for sustained drug release with a potential to be a key player in transdermal delivery of therapeutics. In this paper, an innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported. Gelatin methacryloyl (GelMA) is used as the base for engineering biodegradable MNs. The anticancer drug doxorubicin (DOX) is loaded into GelMA MNs using the one molding step. The GelMA MNs can efficiently penetrate the stratum corneum layer of a mouse cadaver skin. Mechanical properties and drug release behavior of the GelMA MNs can be adjusted by tuning the degree of crosslinking. The efficacy of the DOX released from the GelMA MNs is tested and the anticancer efficacy of the released drugs against melanoma cell line A375 is demonstrated. Since GelMA is a versatile material in engineering tissue scaffolds, it is expected that the GelMA MNs can be used as a platform for the delivery of various therapeutics.

Keywords: gelatin methacryloyl; microneedle; sustained release; transdermal drug delivery.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Administration, Cutaneous
Animals
Biocompatible Materials* / chemistry
Biocompatible Materials* / pharmacology
Doxorubicin* / chemistry
Doxorubicin* / pharmacology
Gelatin / chemistry
Gelatin / pharmacology
Hydrogels* / chemistry
Hydrogels* / pharmacology
Melanoma, Experimental* / drug therapy
Melanoma, Experimental* / metabolism
Melanoma, Experimental* / pathology
Mice
Needles*
Skin Neoplasms* / drug therapy
Skin Neoplasms* / metabolism
Skin Neoplasms* / pathology

Substances

Biocompatible Materials
Hydrogels
Doxorubicin
Gelatin

Abstract

Publication types

MeSH terms

Substances

Grants and funding