Self-Healing Supramolecular Hydrogels for Tissue Engineering Applications

Laura Saunders; Peter X Ma

doi:10.1002/mabi.201800313

Self-Healing Supramolecular Hydrogels for Tissue Engineering Applications

Macromol Biosci. 2019 Jan;19(1):e1800313. doi: 10.1002/mabi.201800313. Epub 2018 Nov 22.

Authors

Laura Saunders¹, Peter X Ma^{1

2

3

4}

Affiliations

¹ Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, 48109, MI, USA.
² Biologic and Materials Science, University of Michigan, Ann Arbor, 48109, MI, USA.
³ Biomedical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.
⁴ Materials Science and Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.

Abstract

Self-healing supramolecular hydrogels have emerged as a novel class of biomaterials that combine hydrogels with supramolecular chemistry to develop highly functional biomaterials with advantages including native tissue mimicry, biocompatibility, and injectability. These properties are endowed by the reversibly cross-linked polymer network of the hydrogel. These hydrogels have great potential for realizing yet to be clinically translated tissue engineering therapies. This review presents methods of self-healing supramolecular hydrogel formation and their uses in tissue engineering as well as future perspectives.

Keywords: biomaterials; hydrogels; self-healing; supramolecular; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Biocompatible Materials* / chemistry
Biocompatible Materials* / pharmacology
Humans
Hydrogels* / chemistry
Hydrogels* / pharmacology
Tissue Engineering / methods*

Substances

Biocompatible Materials
Hydrogels

Abstract

Publication types

MeSH terms

Substances

Grants and funding