Development of Small-Molecule MERS-CoV Inhibitors

Viruses. 2018 Dec 17;10(12):721. doi: 10.3390/v10120721.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.

Keywords: MERS-CoV; mechanism of action; small-molecule inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Coronavirus Infections / drug therapy
  • Drug Discovery
  • Humans
  • Mice
  • Middle East Respiratory Syndrome Coronavirus / drug effects*
  • Middle East Respiratory Syndrome Coronavirus / physiology
  • Pandemics / prevention & control
  • Small Molecule Libraries / pharmacology*
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Small Molecule Libraries