Modified cells as potential ocular drug delivery systems

Tatiana Tennikova; Arto Urtti

doi:10.1016/j.drudis.2018.12.004

Modified cells as potential ocular drug delivery systems

Drug Discov Today. 2019 Aug;24(8):1621-1626. doi: 10.1016/j.drudis.2018.12.004. Epub 2018 Dec 15.

Authors

Tatiana Tennikova¹, Arto Urtti²

Affiliations

¹ Institute of Chemistry, Saint-Petersburg State University, Sankt-Peterburg, Russian Federation. Electronic address: tennikova@mail.ru.
² Institute of Chemistry, Saint-Petersburg State University, Sankt-Peterburg, Russian Federation; Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

PMID: 30562585
DOI: 10.1016/j.drudis.2018.12.004

Abstract

Drug delivery to ocular targets is problematic, especially in retinal disease treatment. Therefore, targeted drug delivery, prolonged drug action, and minimally invasive treatments are needed. In this review, we describe cell technologies for drug delivery. These technologies are based on genetic engineering and nongenetic-based approaches for cell modification. In principle, cell technologies enable targeted delivery, long drug action, and minimally invasive administration, but they have only been sparsely studied for ocular drug delivery. Herein, these technologies are discussed in the ocular context.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Delayed-Action Preparations / therapeutic use
Drug Delivery Systems / methods
Eye / drug effects*
Humans

Substances

Delayed-Action Preparations