Fuelling cancer cells

Nat Rev Endocrinol. 2019 Feb;15(2):71-72. doi: 10.1038/s41574-018-0146-6.

Abstract

Cancer cells consume and utilize glucose at a higher rate than normal cells. However, some microenvironments limit the availability of nutrients and glucose. In 2018, researchers found that tumours depend on a variety of different nutrient sources, both locally and systemically, to overcome metabolic limitations and promote tumour progression and metastasis.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Asparagine / metabolism*
  • Aspartic Acid / metabolism*
  • Disease Progression
  • Female
  • Humans
  • Lactic Acid / metabolism
  • Male
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Oxygen Consumption / physiology
  • Proteins / metabolism
  • Reference Values
  • Tumor Cells, Cultured / metabolism*
  • Tumor Microenvironment*

Substances

  • Proteins
  • Aspartic Acid
  • Lactic Acid
  • Asparagine