Abstract
This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.
Keywords:
Klebsiella pneumoniae; OXA-232; clonal spread; virulence plasmid; virulence potential.
Copyright © 2019 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / therapeutic use
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Base Sequence
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Carbapenem-Resistant Enterobacteriaceae / drug effects
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Carbapenem-Resistant Enterobacteriaceae / genetics*
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Carbapenem-Resistant Enterobacteriaceae / isolation & purification
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China
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Drug Resistance, Multiple, Bacterial / genetics
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Humans
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Immunocompromised Host
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Klebsiella Infections / drug therapy*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Klebsiella pneumoniae / pathogenicity
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Sequence Analysis, DNA
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Virulence / genetics
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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beta-Lactamases
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beta-lactamase OXA-232, Klebsiella pneumoniae