Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker

BMC Immunol. 2018 Dec 17;19(1):38. doi: 10.1186/s12865-018-0280-x.

Abstract

Background: Little is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in AS patients.

Results: Levels of anti-SIRT1 autoantibodies were significantly higher in AS (P < 0.001) and psoriatic arthritis (PsA) (P < 0.01) patients but not rheumatoid arthritis (RA) patients compared with healthy controls. Additionally, titers of anti-NAD-dependent protein deacetylase sirtuin-1(SIRT1) antibodies were significantly higher in AS patients than in RA (P < 0.05) and PsA (P < 0.05) patients. Moreover, levels of anti-SIRT1 (P < 0.001) antibodies were significantly higher during the first year in patients with hip joint involvement. The anti-SIRT1 antibody positivity rate was 18.9% in AS patients.

Conclusions: Our findings indicate that anti-SIRT1 autoantibodies may serve as a marker for diagnosing AS and predicting hip joint involvement at an early stage.

Keywords: AS; Anti-SIRT1 antibodies; Biomarker.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arthritis, Psoriatic / diagnosis
  • Arthritis, Psoriatic / immunology
  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / immunology
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • Biomarkers / blood
  • Female
  • Hip Joint / pathology
  • Humans
  • Male
  • Middle Aged
  • Sirtuin 1 / immunology*
  • Spondylitis, Ankylosing / blood
  • Spondylitis, Ankylosing / diagnosis*
  • Spondylitis, Ankylosing / immunology*

Substances

  • Autoantibodies
  • Biomarkers
  • SIRT1 protein, human
  • Sirtuin 1