Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

Aitor Maestro; Edorta Martinez de Marigorta; Francisco Palacios; Javier Vicario

doi:10.1021/acs.joc.8b02843

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

J Org Chem. 2019 Jan 18;84(2):1094-1102. doi: 10.1021/acs.joc.8b02843. Epub 2019 Jan 7.

Authors

Aitor Maestro¹, Edorta Martinez de Marigorta¹, Francisco Palacios¹, Javier Vicario¹

Affiliation

¹ Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados "Lucio Lascaray"- Facultad de Farmacia , University of the Basque Country , UPV/EHU Paseo de la Universidad 7 , 01006 Vitoria-Gasteiz , Spain.

PMID: 30557510
DOI: 10.1021/acs.joc.8b02843

Abstract

Chiral phosphoric acids efficiently catalyze the asymmetric Friedel-Crafts reaction of several indoles with α-iminophosphonates to afford enantioenriched hybrid α-aminophosphonate functionalized indole derivatives.

Publication types

Research Support, Non-U.S. Gov't