Photoacoustic temperature imaging based on multi-wavelength excitation

Lei Meng; Olivier Deschaume; Lionel Larbanoix; Eduard Fron; Carmen Bartic; Sophie Laurent; Mark Van der Auweraer; Christ Glorieux

doi:10.1016/j.pacs.2018.11.004

Photoacoustic temperature imaging based on multi-wavelength excitation

Photoacoustics. 2018 Nov 22:13:33-45. doi: 10.1016/j.pacs.2018.11.004. eCollection 2019 Mar.

Authors

Lei Meng¹, Olivier Deschaume¹, Lionel Larbanoix², Eduard Fron³, Carmen Bartic¹, Sophie Laurent², Mark Van der Auweraer³, Christ Glorieux¹

Affiliations

¹ Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D - box 2416, 3001 Leuven, Belgium.
² Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland 8, B-6041, Gosselies, Belgium.
³ Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Celestijnenlaan 200F - box 2404, 3001 Leuven, Belgium.

Abstract

Building further upon the high spatial resolution offered by ultrasonic imaging and the high optical contrast yielded by laser excitation of photoacoustic imaging, and exploiting the temperature dependence of photoacoustic signal amplitudes, this paper addresses the question whether the rich information given by multispectral optoacoustic tomography (MSOT) allows to obtain 3D temperature images. Numerical simulations and experimental results are reported on agarose phantoms containing gold nanoparticles and the effects of shadowing, reconstruction flaws, etc. on the accuracy are determined.

Keywords: Absorption coefficient; Finite difference; Multispectral optoacoustic tomography; Photoacoustic imaging.