Lung Cancer Screening with Low-Dose CT: Baseline Screening Results in Shanghai

Li Fan; Yun Wang; Ying Zhou; Qiong Li; Wenjie Yang; Shengping Wang; Fei Shan; Xingwei Zhang; Jingyun Shi; Wufei Chen; Shi-Yuan Liu

doi:10.1016/j.acra.2018.12.002

Lung Cancer Screening with Low-Dose CT: Baseline Screening Results in Shanghai

Acad Radiol. 2019 Oct;26(10):1283-1291. doi: 10.1016/j.acra.2018.12.002. Epub 2018 Dec 14.

Authors

Li Fan¹, Yun Wang¹, Ying Zhou², Qiong Li¹, Wenjie Yang³, Shengping Wang⁴, Fei Shan⁵, Xingwei Zhang⁶, Jingyun Shi⁷, Wufei Chen⁸, Shi-Yuan Liu⁹

Affiliations

¹ Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China.
² Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China; Department of Radiology, The First hospital of Lian Yungang, Xu Zhou Medical University, Lian Yungang, China.
³ Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁴ Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁵ Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
⁶ Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
⁷ Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
⁸ Department of Radiology, Huadong Hospital, Fudan University, Shanghai, China.
⁹ Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China. Electronic address: lsy0930@163.com.

PMID: 30554839
DOI: 10.1016/j.acra.2018.12.002

Abstract

Objective: To report the initial baseline lung cancer screening results with low dose computed tomography (LDCT) in a multicenter study in Shanghai.

Methods: A total of 14,506 subjects underwent LDCT lung cancer screening and completed questionnaires consisting of 13 risk factors for lung cancer in the prospective study. The positive result was defined as any size and density nodule. The nodules were classified into calcified, solid, part-solid, and nonsolid nodules. The positive rate and incidental detection rate of lung cancer and stage I lung cancer were calculated. The proportion of lung nodule and lung cancer with different density and size was analyzed.

Results: The positive rate and incidental detection rate of lung cancer was 29.89% and 1.23%, respectively. The incidental detection rate of stage I lung cancer was 0.97%. The proportion of lung cancer in lung nodules and stage I in lung cancer was 3.48% and 81.09%, respectively. The ratio of nonsolid nodule, part-solid nodule, and solid nodule in lung cancer was 52.94%, 31.93%, and 15.13%, respectively. 74.88% lung nodules were less than 5 mm and 94.12% lung cancers were larger than 5mm in size.

Conclusion: The baseline LDCT lung cancer screening showed subsolid nodules accounted for the majority of lung cancer, and 5 mm in size would be recommended as the positive result threshold.

Keywords: Lung cancer; Screening; Tomography; X-ray computed.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Algorithms
China
Early Detection of Cancer / methods*
Female
Humans
Lung Neoplasms / diagnostic imaging*
Male
Mass Screening / methods*
Middle Aged
Prospective Studies
Radiation Dosage*
Tomography, X-Ray Computed / methods*