A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy

Feifei Sun; Peng Zhang; Yinyin Liu; Chunbo Lu; Yuanhao Qiu; Haibo Mu; Jinyou Duan

doi:10.1016/j.carbpol.2018.11.005

A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy

Carbohydr Polym. 2019 Feb 15:206:309-318. doi: 10.1016/j.carbpol.2018.11.005. Epub 2018 Nov 8.

Authors

Feifei Sun¹, Peng Zhang¹, Yinyin Liu¹, Chunbo Lu¹, Yuanhao Qiu¹, Haibo Mu¹, Jinyou Duan²

Affiliations

¹ College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100, Shaanxi, China.
² College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address: jduan@nwsuaf.edu.cn.

PMID: 30553327
DOI: 10.1016/j.carbpol.2018.11.005

Abstract

In this paper, a novel photo-controlled drug-loaded nanomicelles were self-assembled by the amphiphile of hyaluronan-o-nitrobenzyl-stearyl chain (HA-NB-SC) with doxorubicin (DOX) encapsulated within the hydrophobic core. DOX-loaded HA-NB-SC nanomicelles are ∼139 nm in diameter. CD44-overexpressed HeLa cells can easily take up HA-NB-SC micelles through recognition of HA moiety. DOX-loaded HA-NB-SC nanomicelles could be disassembled upon UV light (365 nm) and consequently, release DOX at desired pathological sites. Furtherly, nitrosobenzaldehyde derivative, photo-induced products of HA-NB-SC and DOX could inhibit the proliferation of HeLa cells together. This strategy may shed some light on delivery of hydrophobic anti-cancer drugs in a controlled manner.

Keywords: Hyaluronan; Nanomicelles; Photo-controlled; Targeted delivery.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Doxorubicin / chemistry
Doxorubicin / pharmacology*
Drug Carriers / chemical synthesis
Drug Carriers / chemistry*
Drug Carriers / radiation effects
Drug Carriers / toxicity
Drug Liberation
HEK293 Cells
HeLa Cells
Humans
Hyaluronic Acid / analogs & derivatives*
Hyaluronic Acid / chemical synthesis
Hyaluronic Acid / radiation effects
Hyaluronic Acid / toxicity
Light
Micelles
Nanostructures / chemistry*
Nanostructures / radiation effects
Nanostructures / toxicity
Nitrobenzoates / chemical synthesis
Nitrobenzoates / chemistry
Nitrobenzoates / radiation effects
Nitrobenzoates / toxicity
Particle Size
Surface-Active Agents / chemical synthesis
Surface-Active Agents / chemistry*
Surface-Active Agents / radiation effects
Surface-Active Agents / toxicity

Substances

Antineoplastic Agents
Drug Carriers
Micelles
Nitrobenzoates
Surface-Active Agents
Doxorubicin
Hyaluronic Acid