[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis]

Abstract

Objective: To observe the clinical efficacy of nasal corticosteroids combined with nasal antihistamine in the treatment of vasomotor rhinitis. Method: One hundred and twenty vasomotor rhinitis patients were randomly divided into three groups including budesonide group, azelastine group, and budesonide and azelastine group with 40 cases in each. Nasal spray with nasal corticosteroids and nasal antihistamines was applied for combined treatment group, while the patients in budesonide group and azelastine group were given only nasal corticosteroids and nasal antihistamines, respectively. The course lasted 8 weeks, and the clinical efficacy was evaluated with the visual analogue scale (VAS) score and SF-12v2 score. Result: VAS score of the peripheral nasal symptoms of the three groups was significantly decreased after treatment, and the difference was statistically significant compared with that before treatment (P<0.05). The visual analogue scale of nasal symptoms in the combined treatment group was significantly lower than that in the budesonide group and the azelastine group. There was no statistically significant difference between the budesonide group and the azelastine group after the treatment on the VAS of the three nasal symptoms. However, compared with before treatment, the difference was statistically significant (P<0.05). The visual analogue scale of nasal symptoms in the combined treatment group was higher than that in the budesonide group and the azelastine group, and the difference was statistically significant (P<0.05). After treatment, there was no significant difference between budesonide group and azelastine group (P>0.05). At the same time, the patients in the combined treatment group showed significant efficiency of 47.50% and total efficiency of 90.00%, which were statistically significant compared with budesonide group (30.00%,75.00%) and azelastine group (27.50, 70.00%), respectively (P<0.05). But there was no significant difference between budesonide group and azelastine group (P>0.05). Conclusion: Nasal corticosteroids and nasal antihistamine can effectively relieve the nasal symptoms of vasomotor rhinitis and improve the quality of life of patients. The effect of nasal corticosteroids was better than that of nasal antihistamine. The effect of nasal corticosteroids combined with nasal antihistamine was superior to that of single drug..

Keywords: combination; nasal antihistamine; nasal corticosteroids; vasomotor rhinitis.