Warming up the tumor microenvironment in order to enhance immunogenicity

Marion Humbert; Stephanie Hugues

doi:10.1080/2162402X.2018.1510710

Warming up the tumor microenvironment in order to enhance immunogenicity

Oncoimmunology. 2018 Oct 1;8(1):e1510710. doi: 10.1080/2162402X.2018.1510710. eCollection 2019.

Authors

Marion Humbert¹, Stephanie Hugues¹

Affiliation

¹ Department of Pathology and Immunology, University of Geneva Medical School, Gemeva, Switzerland.

Abstract

We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses.

Keywords: CpG-B; local immunotherapy; tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't

Grants and funding

This work was supported by the European Research Council [281365];Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [PP00P3_152951]; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [310030_166541].