Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

Daniel F Sauer; Johannes Schiffels; Takashi Hayashi; Ulrich Schwaneberg; Jun Okuda

doi:10.3762/bjoc.14.265

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

Beilstein J Org Chem. 2018 Nov 19:14:2861-2871. doi: 10.3762/bjoc.14.265. eCollection 2018.

Authors

Daniel F Sauer¹, Johannes Schiffels², Takashi Hayashi³, Ulrich Schwaneberg², Jun Okuda¹

Affiliations

¹ Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
² Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
³ Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.

Abstract

This review summarizes the recent progress of Grubbs-Hoveyda (GH) type olefin metathesis catalysts incorporated into the robust fold of β-barrel proteins. Anchoring strategies are discussed and challenges and opportunities in this emerging field are shown from simple small-molecule transformations over ring-opening metathesis polymerizations to in vivo olefin metathesis.

Keywords: artificial metalloprotein; metathease; olefin metathesis; ruthenium; β-barrel protein.

Publication types

Review