Stroke is a leading cause of adult disability in the United States. However, limited number of molecularly targeted therapy exists for stroke. Recent studies have shown that Li-pocalin-2 (LCN2) is an acute phase protein mediating neuroinflammation after ischemic and hemorrhagic strokes. This review is an attempt to summarize some LCN2-related research findings and discuss its role in stroke.
Keywords: 24p3; Biomarker; Lipocalin-2; NGAL; Neutrophil; PKC; Phosphorylation; Reperfusion injury; Stroke.