Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial

Aging Clin Exp Res. 2019 Oct;31(10):1517-1524. doi: 10.1007/s40520-018-1090-y. Epub 2018 Dec 11.

Abstract

Background: Physical exercise and nutrition seem to have a key role in the management of hip fracture patients.

Aim: To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients.

Methods: In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. We randomly assigned the participants into two groups (A and B). Both groups performed a physical exercise rehabilitative programme (five sessions of 40 min/week for 2 weeks, followed by a home-based exercise protocol) and received a dietetic counseling; only group A was supplemented with two sachets of 4 g/day of essential amino acids (Aminotrofic®). We evaluated at baseline and after 2 months of intervention (T1): hand grip strength, Timed Up and Go, and Iowa Level of Assistance scale (ILOA).

Results: The 32 hip fracture patients (mean aged 79.03 ± 7.80 years) were allocated into two groups: group A (n = 16) and group B (n = 16). All the participants showed significant differences in all outcomes at T1 (p < 0.017). Sarcopenic patients in group A (n = 10) showed statistically significant differences in all the primary outcomes at T1 (p < 0.017), whereas sarcopenic patients in group B (n = 13) showed a significant reduction of ILOA only. In non-sarcopenic patients, we found no differences at T1 in all outcome measures.

Discussion: Hip fractures are a complex multifactorial condition of the elderly that determines devastating effects on functioning and independence.

Conclusion: A multidisciplinary rehabilitative and nutritional intervention seems to be effective on functioning in hip fracture patients, in particular sarcopenic ones.

Keywords: Amino acids; Hip fractures; Muscle strength; Nutrition; Rehabilitation; Sarcopenia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amino Acids, Essential / therapeutic use*
  • Dietary Supplements*
  • Exercise Therapy / methods
  • Female
  • Hand Strength
  • Hip Fractures / diet therapy*
  • Hip Fractures / rehabilitation*
  • Humans
  • Male
  • Outcome Assessment, Health Care
  • Pilot Projects
  • Sarcopenia

Substances

  • Amino Acids, Essential