Going the distance: Neocentromeres make long-range contacts with heterochromatin

Shannon M McNulty; Beth A Sullivan

doi:10.1083/jcb.201811172

Going the distance: Neocentromeres make long-range contacts with heterochromatin

J Cell Biol. 2019 Jan 7;218(1):5-7. doi: 10.1083/jcb.201811172. Epub 2018 Dec 11.

Authors

Shannon M McNulty¹, Beth A Sullivan²

Affiliations

¹ Department of Molecular Genetics and Microbiology, Division of Human Genetics, Duke University Medical Center, Durham, NC.
² Department of Molecular Genetics and Microbiology, Division of Human Genetics, Duke University Medical Center, Durham, NC beth.sullivan@duke.edu.

Abstract

Neocentromeres are ectopic centromeres that form at noncanonical, usually nonrepetitive, genomic locations. Nishimura et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805003) explore the three-dimensional architecture of vertebrate neocentromeres, leading to a model for centromere function and maintenance via nuclear clustering with heterochromatin.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Nucleus
Centromere Protein A
Centromere*
Genomics
Heterochromatin*

Substances

Centromere Protein A
Heterochromatin

Grants and funding

R01 GM124041/GM/NIGMS NIH HHS/United States