From Basic Knowledge to Effective Therapies

Daniel B Lipka; Pavlo Lutsik; Christoph Plass

doi:10.1016/j.ccell.2018.11.013

From Basic Knowledge to Effective Therapies

Cancer Cell. 2018 Dec 10;34(6):871-873. doi: 10.1016/j.ccell.2018.11.013.

Authors

Daniel B Lipka¹, Pavlo Lutsik², Christoph Plass³

Affiliations

¹ Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany; Department of Hematology and Oncology, Medical Center, Otto-von-Guericke-University, Magdeburg, Germany.
² Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany.
³ Division of Cancer Epigenomics, German Cancer Research Center, Heidelberg, Germany; The German Cancer Research Consortium. Electronic address: c.plass@dkfz.de.

PMID: 30537508
DOI: 10.1016/j.ccell.2018.11.013

Abstract

In this issue of Cancer Cell, Ott et al. use integrative analysis of histone ChIP-seq and ATAC-seq to describe enhancer-based regulatory circuits in chronic lymphocytic leukemia. This work identified and validated transcription factor PAX5 as main driver of an oncogenic circuitry, which can be disrupted by BET bromodomain inhibition.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Histones
Humans
Leukemia, Lymphocytic, Chronic, B-Cell*
Nuclear Proteins
Transcription Factors

Substances

Histones
Nuclear Proteins
Transcription Factors