Thermo-sensitive nanogel-laden bicontinuous microemulsion drug-eluting contact lenses

J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1159-1169. doi: 10.1002/jbm.b.34209. Epub 2018 Dec 7.

Abstract

The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Nanoporous BMCLs containing thermosensitive TM-laden nanogel were capable of potent body-temperature-triggered release of TM. Daily drug release was controllable according to the initial volume of drug-loaded (VDL) and loading method for sustained drug release, making them reduce drug-loss during transportation or storage. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1159-1169, 2019.

Keywords: bicontinuous microemulsion; drug delivery; drug-eluting contact lens; nanoporous contact lens; sustained drug release; temperature-triggered drug release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Contact Lenses*
  • Drug Implants / chemistry
  • Drug Implants / pharmacokinetics
  • Drug Implants / pharmacology
  • Emulsions
  • Glaucoma / drug therapy*
  • Hot Temperature*
  • Humans
  • Nanogels / chemistry*
  • Porosity
  • Timolol* / chemistry
  • Timolol* / pharmacokinetics
  • Timolol* / pharmacology

Substances

  • Acrylic Resins
  • Drug Implants
  • Emulsions
  • Nanogels
  • poly-N-isopropylacrylamide
  • Timolol