High Mortality of Non-Fournier Necrotizing Fasciitis With Enterobacteriales: Time to Rethink Classification?

Clin Infect Dis. 2019 Jun 18;69(1):147-150. doi: 10.1093/cid/ciy1011.

Abstract

This cohort study describes mortality predictors of necrotizing fasciitis (NF). Higher age, chronic kidney disease, and higher Charlson score increased the mortality rate. Mortality was >3 times higher in monomicrobial gram-negative NF than in type I or type II NF. Highest mortality was found with Enterobacteriales in non-Fournier NF.

Keywords: Enterobacteriaceae; Fournier gangrene; microbiology; necrotizing soft tissue infection; outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Enterobacteriaceae / classification*
  • Enterobacteriaceae / pathogenicity
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / mortality*
  • Fasciitis, Necrotizing / classification
  • Fasciitis, Necrotizing / microbiology*
  • Fasciitis, Necrotizing / mortality*
  • Female
  • Fournier Gangrene
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tertiary Care Centers / statistics & numerical data