The genetics of cutaneous squamous cell carcinogenesis

Eur J Dermatol. 2018 Oct 1;28(5):597-605. doi: 10.1684/ejd.2018.3403.

Abstract

In this review, the current knowledge of cutaneous squamous cell carcinogenesis (cSCC) is outlined based on an appraisal of the different features of cSCC, with particular emphasis on genetic alterations underlying aetiopathogenesis. When appropriate, diagnostic and/or prognostic biomarkers for cSCC are also considered. This review is intended to aid future investigation into the molecular characterization of cSCC.

Keywords: cSCC; carcinogenesis; cutaneous squamous cell carcinoma; genetics.

Publication types

  • Systematic Review

MeSH terms

  • Carcinogenesis / pathology*
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Cell Cycle Proteins / genetics
  • Cyclin D1 / genetics
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Microtubule-Associated Proteins / genetics
  • Mutation
  • Prevalence
  • Retinoblastoma Binding Proteins / genetics
  • Risk Assessment
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology
  • Tumor Suppressor Protein p53 / genetics
  • Ubiquitin-Protein Ligases / genetics

Substances

  • Cell Cycle Proteins
  • KNSTRN protein, human
  • Microtubule-Associated Proteins
  • RB1 protein, human
  • Retinoblastoma Binding Proteins
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Cyclin D1
  • Ubiquitin-Protein Ligases