Background: The correlation between CYP11B2 rs1799998 polymorphism and atrial fibrillation (AF) was analyzed by several studies, but the results of these studies were inconsistent. Thus, we performed this study to obtain a more conclusive result on relationship between CYP11B2 rs1799998 polymorphism and AF.
Methods: Eligible studies were searched in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of correlation.
Results: A total of 12 studies with 5466 participants were analyzed. We found that CYP11B2 rs1799998 polymorphism was significantly associated with AF in overall population under recessive genetic model with FEM (P = 0.005, OR = 1.29, 95%CI 1.08-1.54), but no positive results were detected in overall analyses with REMs. Further subgroup analyses revealed that CYP11B2 rs1799998 polymorphism was significantly correlated with AF in East Asians, but not in West Asians. Furthermore, significant associations between rs1799998 polymorphism and AF were observed in subjects with essential hypertension (EH) and heart failure (HF). No any other positive results were found in overall and subgroup analyses.
Conclusions: Overall, our meta-analysis suggested that rs1799998 polymorphism may serve as a potential biological marker of AF in East Asians and subjects with EH or HF.
Keywords: Aldosterone synthase (CYP11B2); Atrial fibrillation (AF); Gene polymorphism; Meta-analysis.
Copyright © 2018. Published by Elsevier Inc.