Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Yu-Jung Lin; Fwu-Long Mi; Po-Yen Lin; Yang-Bao Miao; Tringyo Huang; Kuan-Hung Chen; Chiung-Tong Chen; Yen Chang; Hsing-Wen Sung

doi:10.1016/j.addr.2018.12.001

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Adv Drug Deliv Rev. 2019 Jan 15:139:71-82. doi: 10.1016/j.addr.2018.12.001. Epub 2018 Dec 6.

Authors

Yu-Jung Lin¹, Fwu-Long Mi², Po-Yen Lin¹, Yang-Bao Miao¹, Tringyo Huang¹, Kuan-Hung Chen¹, Chiung-Tong Chen³, Yen Chang⁴, Hsing-Wen Sung⁵

Affiliations

¹ Department of Chemical Engineering, Institute of Biomedical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan, ROC.
² Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
³ Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan, ROC.
⁴ Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
⁵ Department of Chemical Engineering, Institute of Biomedical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address: hwsung@mx.nthu.edu.tw.

PMID: 30529306
DOI: 10.1016/j.addr.2018.12.001

Abstract

The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.

Keywords: Alternative routes; Diabetes mellitus; Glucose sensing; Insulin delivery; Stimuli-responsiveness.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Diabetes Mellitus / drug therapy*
Drug Administration Routes
Humans
Hypoglycemic Agents / administration & dosage*
Insulin / administration & dosage*

Substances

Hypoglycemic Agents
Insulin