Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia

Xianming Su; Li Li; Hua Sun; Fan Zhang; Changkang Li; Fenghua Li; Hongqing Wang; Baoming Li; Ruoyun Chen; Jie Kang

doi:10.1016/j.bioorg.2018.11.055

Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia

Bioorg Chem. 2019 Jun:87:867-875. doi: 10.1016/j.bioorg.2018.11.055. Epub 2018 Dec 3.

Authors

Xianming Su¹, Li Li², Hua Sun³, Fan Zhang⁴, Changkang Li¹, Fenghua Li⁵, Hongqing Wang⁶, Baoming Li⁷, Ruoyun Chen⁸, Jie Kang⁹

Affiliations

¹ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China.
² State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: annaleelin@imm.ac.cn.
³ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: sunhua@imm.ac.cn.
⁴ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: fanfanzhang@imm.ac.cn.
⁵ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: lifenghua@imm.ac.cn.
⁶ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: wanghongqing@imm.ac.cn.
⁷ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: libaoming@imm.ac.cn.
⁸ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: rych@imm.ac.cn.
⁹ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China. Electronic address: jiekang@imm.ac.cn.

PMID: 30528930
DOI: 10.1016/j.bioorg.2018.11.055

Abstract

Eight new glycosides, morindaparvins P-W, were isolated from the butanol extract of the aerial parts of Morinda parvifolia. These new structures were elucidated by comprehensive spectroscopic analysis and by comparing the experimental and calculated electronic circular dichroism spectra. The butanol extract was observed to significantly reduce the levels of alanine aminotransferase, aspartate transaminase, and lactate dehydrogenase in the sera of mice with concanavalin A-induced hepatitis. At a concentration of 10 μM, five compounds (1, and 4-7) isolated from the butanol extract possessed hepatoprotective activities against the damage induced by acetaminophen in human HepG2 liver cancer cells.

Keywords: Glycosides; Hepatoprotection; Morinda parvifolia Bartl. ex DC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Glycosides / chemistry
Glycosides / isolation & purification
Glycosides / pharmacology*
Hep G2 Cells
Humans
Liver Neoplasms / chemically induced
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Liver Neoplasms, Experimental / chemically induced
Liver Neoplasms, Experimental / drug therapy
Liver Neoplasms, Experimental / pathology
Male
Mice
Mice, Inbred ICR
Molecular Structure
Morinda / chemistry*
Plant Components, Aerial / chemistry*
Protective Agents / chemistry
Protective Agents / isolation & purification
Protective Agents / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Protective Agents
Acetaminophen