Does stromal interaction molecule-1 have five senses?

Peter B Stathopulos; Mitsuhiko Ikura

doi:10.1016/j.ceca.2018.12.001

Does stromal interaction molecule-1 have five senses?

Cell Calcium. 2019 Jan:77:79-80. doi: 10.1016/j.ceca.2018.12.001. Epub 2018 Dec 3.

Authors

Peter B Stathopulos¹, Mitsuhiko Ikura²

Affiliations

¹ Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON, N6A 5C1, Canada. Electronic address: pstatho@uwo.ca.
² Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada. Electronic address: mikura@uhnresearch.ca.

PMID: 30528613
DOI: 10.1016/j.ceca.2018.12.001

Abstract

A single calcium (Ca²⁺) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca²⁺ channels. Recent work by Gudlur et al., published in Nat Commun [9(1):4536], suggests that the STIM1 endoplasmic reticulum (ER) luminal domain has ∼5 additional Ca²⁺ binding sites, which underlie a surprising new proposal for Ca²⁺ sensing.

Keywords: Calcium sensing; EF-hand; EFSAM; Stromal interaction molecule-1.

Publication types

Comment

MeSH terms

Binding Sites
Calcium Channels
Calcium*
Endoplasmic Reticulum*
Protein Domains
Stromal Interaction Molecule 1

Substances

Calcium Channels
Stromal Interaction Molecule 1
Calcium