Alectinib is effective, safe and tolerable in an adolescent with stage IVB ALK-rearranged adenocarcinoma of the lung

Ben W R Balzer; Christine Loo; Eva A Wegner; Christa E Nath; Samiuela Lee; Chantelle Smith; Craig R Lewis; Toby N Trahair; Antoinette C Anazodo

doi:10.1080/08880018.2018.1541492

Alectinib is effective, safe and tolerable in an adolescent with stage IVB ALK-rearranged adenocarcinoma of the lung

Pediatr Hematol Oncol. 2018 Oct-Nov;35(7-8):415-421. doi: 10.1080/08880018.2018.1541492. Epub 2018 Dec 9.

Authors

Ben W R Balzer^{1

2}, Christine Loo³, Eva A Wegner^{4

5}, Christa E Nath^{6

7}, Samiuela Lee⁶, Chantelle Smith⁸, Craig R Lewis^{5

9}, Toby N Trahair^{1

2

10}, Antoinette C Anazodo^{1

2

10

11}

Affiliations

¹ a Sydney Children's Hospital , Randwick , New South Wales , Australia.
² b School of Women's and Children's Health , University of New South Wales , Randwick , New South Wales , Australia.
³ c Department of Anatomical Pathology , NSW Health Pathology, Prince of Wales Hospital , Randwick , New South Wales , Australia.
⁴ d Department of Nuclear Medicine and PET , Prince of Wales Hospital , Randwick , New South Wales , Australia.
⁵ e Prince of Wales Clinical School , University of New South Wales , Randwick , New South Wales , Australia.
⁶ f Department of Biochemistry , The Children's Hospital at Westmead , Westmead , New South Wales , Australia.
⁷ g Faculty of Pharmacy , University of Sydney , Camperdown , New South Wales , Australia.
⁸ h Pharmacy Department , Sydney Children's Hospital , Randwick , New South Wales , Australia.
⁹ i Department of Medical Oncology , Prince of Wales Hospital , Randwick , New South Wales , Australia.
¹⁰ j Sydney Children's Hospital , Kids Cancer Centre , Randwick , New South Wales , Australia.
¹¹ k Prince of Wales Hospital , Nelune Comprehensive Cancer Centre , Randwick , New South Wales , Australia.

PMID: 30526220
DOI: 10.1080/08880018.2018.1541492

Abstract

Anaplastic lymphoma kinase (ALK) inhibitors such as crizotinib and alectinib have been shown to have significant activity in ALK-rearranged non-small cell lung cancers (NSCLC). There are no data for alectinib's safety or efficacy in younger patients, though it is superior to crizotinib in adult trials. We present a 14-year old girl diagnosed with stage IV-B ALK-positive adenocarcinoma of the lung after presenting with cough and fever. She was commenced on alectinib at adult dose and has had sustained complete metabolic remission for 9 months. She is the youngest patient with lung adenocarcinoma to be treated with alectinib.

Keywords: Lung cancer; adenocarcinoma; adolescent; alectinib.

Publication types

Case Reports

MeSH terms

Adenocarcinoma of Lung / drug therapy*
Adenocarcinoma of Lung / enzymology
Adenocarcinoma of Lung / pathology
Adolescent
Anaplastic Lymphoma Kinase*
Carbazoles / administration & dosage*
Female
Humans
Lung Neoplasms / drug therapy*
Lung Neoplasms / enzymology
Lung Neoplasms / pathology
Neoplasm Staging
Piperidines / administration & dosage*

Substances

Carbazoles
Piperidines
ALK protein, human
Anaplastic Lymphoma Kinase
alectinib