Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD

Felipe Almeida Picon; João Ricardo Sato; Maurício Anés; Leonardo Modesti Vedolin; Alessandro André Mazzola; Bruna Bressan Valentini; Renata Basso Cupertino; Rafael Gomes Karam; Marcelo Moraes Victor; Vitor Breda; Katiane Silva; Neivo da Silva Jr; Claiton Henrique Dotto Bau; Eugenio Horacio Grevet; Luis Augusto Paim Rohde

doi:10.1177/1087054718816822

Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD

J Atten Disord. 2020 Feb;24(3):447-455. doi: 10.1177/1087054718816822. Epub 2018 Dec 10.

Authors

Felipe Almeida Picon^{1

2

3}, João Ricardo Sato^{3

4}, Maurício Anés^{1

2}, Leonardo Modesti Vedolin⁵, Alessandro André Mazzola⁶, Bruna Bressan Valentini⁷, Renata Basso Cupertino^{1

8}, Rafael Gomes Karam¹, Marcelo Moraes Victor^{1

2}, Vitor Breda^{1

2}, Katiane Silva^{1

2}, Neivo da Silva Jr⁹, Claiton Henrique Dotto Bau^{1

2

8}, Eugenio Horacio Grevet^{1

2}, Luis Augusto Paim Rohde^{1

2

3}

Affiliations

¹ ADHD Outpatient Program - Adult Division, Hospital de Clínicas de Porto Alegre, Brazil.
² Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
³ National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
⁴ Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo André, Brazil.
⁵ Grupo DASA, São Paulo, Brazil.
⁶ PhyMED Medical Physics and Radioprotection Consulting, Porto Alegre, Brazil.
⁷ Hospital Moinhos de Vento, Porto Alegre, Brazil.
⁸ Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
⁹ Nuclear Medicine Laboratory, Santa Casa de Misericórdia, Porto Alegre, Brazil.

PMID: 30526190
DOI: 10.1177/1087054718816822

Abstract

Objective: This study evaluated the hypothesis that methylphenidate immediate release (MPH-IR) treatment would improve Default Mode Network (DMN) within-connectivity. Method: Resting-state functional connectivity of the main nodes of DMN was evaluated in a highly homogeneous sample of 18 drug-naive male adult participants with ADHD. Results: Comparing resting-state functional connectivity functional magnetic resonance imaging (R-fMRI) scans before and after MPH treatment focusing exclusively on within-DMN connectivity, we evidenced the strengthening of functional connectivity between two nodes of the DMN: posterior cingulate cortex (PCC) and left lateral parietal cortex (LLP). Conclusion: Our results contribute to the further understanding on how MPH affects functional connectivity within DMN of male adults with ADHD and corroborate the hypothesis of ADHD being a delayed neurodevelopmental disorder.

Keywords: ADHD; MPH; fMRI; intrinsic connectivity; resting-state functional connectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Attention Deficit Disorder with Hyperactivity* / diagnostic imaging
Attention Deficit Disorder with Hyperactivity* / drug therapy
Brain / diagnostic imaging
Brain Mapping
Gyrus Cinguli / diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Methylphenidate* / pharmacology
Methylphenidate* / therapeutic use

Substances

Methylphenidate