Phase-contrast breast CT: the effect of propagation distance

Phys Med Biol. 2018 Dec 18;63(24):24NT03. doi: 10.1088/1361-6560/aaf2e1.

Abstract

X-ray phase imaging has the potential to dramatically improve soft tissue contrast sensitivity, which is a crucial requirement in many diagnostic applications such as breast imaging. In this context, a program devoted to perform in vivo phase-contrast synchrotron radiation breast computed tomography is ongoing at the Elettra facility (Trieste, Italy). The used phase-contrast technique is the propagation-based configuration, which requires a spatially coherent source and a sufficient object-to-detector distance. In this work the effect of this distance on image quality is quantitatively investigated scanning a large breast surgical specimen at three object-to-detector distances (1.6, 3, 9 m) and comparing the images both before and after applying the phase-retrieval procedure. The sample is imaged at 30 keV with a [Formula: see text] pixel pitch CdTe single-photon-counting detector, positioned at a fixed distance of 31.6 m from the source. The detector fluence is kept constant for all acquisitions. The study shows that, at the largest distance, a 20-fold SNR increase can be obtained by applying the phase-retrieval procedure. Moreover, it is shown that, for phase-retrieved images, changing the object-to-detector distance does not affect spatial resolution while boosting SNR (four-fold increase going from the shortest to the largest distance). The experimental results are supported by a theoretical model proposed by other authors, whose salient results are presented in this paper.

MeSH terms

  • Breast / abnormalities*
  • Breast / diagnostic imaging
  • Breast Neoplasms / diagnostic imaging*
  • Female
  • Humans
  • Hypertrophy / diagnostic imaging*
  • Image Processing, Computer-Assisted / methods*
  • Microscopy, Phase-Contrast / methods*
  • Models, Theoretical
  • Quantum Dots*
  • Synchrotrons / instrumentation*
  • Tomography, X-Ray Computed / methods*

Supplementary concepts

  • Gigantomastia