Objective: To obtain HIV incidence among injection drug users (IDU) and female sex workers (FSW) in Dehong Prefecture, Yunnan Province during 2009-2017. Methods: We recruited drug users and female sex workers from all sentinel surveillance sites across Dehong Prefecture during 2009-2017. A total of 10 480 IDU and 18 126 FSW in Dehong Prefecture were recruited by fingerprint technique. Data about drug uses, commercial sexual behavior, sociodemographic characteristics was collected by structured questionnaire. HIV-positive patients who were long-term infected or with CD4(+) T cell count was ≤200 were not included for further HIV incidence testing. Also, those who self-identified as on antiretroviral treatment (ART) or AIDS cases were also excluded. A total of 841 and 157 plasma specimens from IDU and FSW that met the inclusion criterion were finally included, respectively. Limiting antigen avidity enzyme immunoassay(LAg-Avidity EIA) were performed to calculate the HIV incidence among these two sub-populations. Results: A total of 3 444 IDU were HIV-positive, among which 884 (25.7%) were Burmese with age of (30.4±7.7), and 2 560 were Chinese with age of (36.6±7.3). Among 228 HIV-positive FSW, 109 (47.8%) were Burmese with age of (27.1±6.3), 119 (52.5%) were Chinese with age of (29.9±11.1). For IDU, the estimated HIV incidence among Burmese in 2009-2010, 2011-2012, 2013-2014, 2015-2017 was 4.20% (95%CI: -0.55%-8.95%), 7.75% (95%CI: 2.95%-12.55%), 11.79% (95%CI: 5.38%-18.20%), 10.30% (95%CI: 5.67%-14.94%), respectively, while Chinese were 3.11% (95%CI: 1.59%-4.64%), 0.03% (95%CI: -0.03%-0.08%), 1.55% (95%CI: 0.54%-2.57%), 0.58% (95%CI: -0.06%-1.04%), respectively. In 2009-2011, 2012-2014, 2015-2017, estimated HIV incidence among Burmese FSW was 0.22% (95%CI: -0.21%-0.64%), 1.24%(95%CI: 0.15%-2.32%), 0.55%(95%CI: 0.01%-1.08%). Whereas, estimated HIV incidence among Chinese FSW was 0.62% (95%CI: 0.25%-0.98%), 0.11% (95%CI: -0.04%-0.26%), 0.22% (95%CI: 0-0.44%). Conclusion: HIV incidences among Chinese IDU and FSW are on the downward trend, while Burmese IDU and FSW seem to be gaining momentum.
目的： 了解2009—2017年云南省德宏傣族景颇族自治州（德宏州）静脉注射吸毒人群（IDU）和暗娼HIV新发感染情况。 方法： 以"德宏州HIV指纹数据库系统"为数据库，纳入2009—2017年德宏州5个县市戒毒所监测点每年新入的IDU，以及暗娼工作场所监测点的暗娼为研究对象，分别为10 480和18 126名，收集其吸毒相关行为、提供性服务相关行为、社会学和人口学信息等。排除IDU和暗娼HIV抗体阳性者中既往阳性、CD4(+)T淋巴细胞计数≤200个/μl、艾滋病患者及接受抗病毒治疗者后，符合LAg-Avidity EIA检测的IDU为841例，暗娼为157例，计算IDU HIV校正新发感染率、暗娼HIV未校正新发感染率。 结果： IDU中共有3 444例HIV感染者，缅甸籍884例（25.7%），年龄为（30.4±7.7）岁；中国籍2 560例（74.3%），年龄为（36.6±7.3）岁。暗娼中共有228例HIV感染者，缅甸籍109例（47.8%），年龄为（27.1±6.3）岁；中国籍119例（52.2%），年龄为（29.9±11.1）岁。2009—2010、2011—2012、2013—2014、2015—2017年缅甸籍IDU HIV校正新发感染率分别为4.20%（95%CI：-0.55%~8.95%）、7.75%（95%CI：2.95%~12.55%）、11.79%（95%CI：5.38%~18.20%）、10.30%（95%CI：5.67%~14.94%），中国籍分别为3.11%（95%CI：1.59%~4.64%）、0.03%（95%CI：-0.03%~0.08%）、1.55%（95%CI：0.54%~2.57%）、0.58%（95%CI：-0.06%~1.04%）；2009—2011、2012—2014、2015—2017年缅甸籍暗娼HIV校正新发感染率分别为0.22%（95%CI：-0.21%~0.64%）、1.24%（95%CI：0.15%~2.32%）、0.55%（95%CI：0.01%~1.08%），中国籍分别为0.62%（95%CI：0.25%~0.98%）、0.11%（95%CI：-0.04%~0.26%）、0.22%（95%CI：0~0.44%）。 结论： 中国籍IDU和暗娼HIV新发感染率呈下降趋势，缅甸籍呈上升趋势。.
Keywords: Cross-sectional study; Female sex workers; HIV; Injection drug users; Limiting antigen avidity enzyme immunoassay.