Physiological Models of Human Neuronal Development and Disease

Mohammed A Mostajo-Radji; Alex A Pollen

doi:10.1016/j.neuron.2018.11.026

Physiological Models of Human Neuronal Development and Disease

Neuron. 2018 Dec 5;100(5):1025-1027. doi: 10.1016/j.neuron.2018.11.026.

Authors

Mohammed A Mostajo-Radji¹, Alex A Pollen²

Affiliations

¹ Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: mohammed.mostajoradji@ucsf.edu.
² Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: alex.pollen@ucsf.edu.

PMID: 30521777
DOI: 10.1016/j.neuron.2018.11.026

Abstract

Human neural network development occurs at stages inaccessible to longitudinal monitoring. By transplanting human neurons to the adult mouse brain, recent studies explore human neural circuit formation in realistic cellular and physiological environments, establishing new models for human neurodevelopmental disorders.

MeSH terms

Animals
Brain / growth & development*
Brain / physiopathology*
Humans
Mice
Neural Pathways / growth & development
Neural Pathways / physiopathology
Neurodevelopmental Disorders / physiopathology*
Neurons / physiology
Organoids / growth & development