Astrocytes "Chordinate" Synapse Maturation and Plasticity

Katherine T Baldwin; Cagla Eroglu

doi:10.1016/j.neuron.2018.11.027

Astrocytes "Chordinate" Synapse Maturation and Plasticity

Neuron. 2018 Dec 5;100(5):1010-1012. doi: 10.1016/j.neuron.2018.11.027.

Authors

Katherine T Baldwin¹, Cagla Eroglu²

Affiliations

¹ Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
² Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences (DIBS), Durham, NC 27710, USA. Electronic address: cagla.eroglu@duke.edu.

PMID: 30521771
DOI: 10.1016/j.neuron.2018.11.027

Abstract

A key step in excitatory synapse maturation is the switch in AMPA receptor subunit composition to GluA2-containing calcium-impermeable receptors. Now, Blanco-Suarez et al. (2018) demonstrate that astrocyte-secreted chordin-like 1 drives this process, enabling synapse maturation and limiting plasticity.

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MeSH terms

Astrocytes*
Glycoproteins
Intercellular Signaling Peptides and Proteins
Receptors, AMPA*
Synapses

Substances

Glycoproteins
Intercellular Signaling Peptides and Proteins
Receptors, AMPA
chordin