Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells

Malena Rabenau; Matthias Unger; Jürgen Drewe; Carsten Culmsee

doi:10.1016/j.dib.2018.10.092

Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells

Data Brief. 2018 Oct 26:21:1872-1879. doi: 10.1016/j.dib.2018.10.092. eCollection 2018 Dec.

Authors

Malena Rabenau^{1

2}, Matthias Unger³, Jürgen Drewe³, Carsten Culmsee^{1

2}

Affiliations

¹ Institut für Pharmakologie und Klinische Pharmazie, Biochemisch-Pharmakologisches Centrum Marburg, Philipps-Universität Marburg, Karl-von-Frisch-Straße 1, 35032 Marburg, Germany.
² Center for Mind Brain and Behavior, 35032 Marburg, Germany.
³ Preclinical Research, Max Zeller Soehne AG, Romanshorn, Switzerland.

Abstract

This data article describes the influence of Cimicifuga racemosa extract Ze 450 on neuronal cells in models of glutamate-induced excitotoxicity and cell death induced by oxidative stress. Effects of Ze 450 on glutamate-mediated excitotoxicity were assessed in primary cortical rat and mouse neurons and, further, glutamate-mediated oxidative stress was analyzed in HT22 cells lacking ionotropic glutamate receptors. This study especially focusses on mitochondrial parameters like mitochondrial ROS formation, mitochondrial membrane potential, ATP production and mitochondrial integrity. Further the effects of Ze 450 on lipid-peroxidation, metabolic activity, cell proliferation and cell death were assessed under control conditions and oxidative challenge evoked by millimolar concentrations of glutamate in HT22 cells. These data support the findings in HT22, mHypo and HepG2 liver cells (Rabenau et al., 2018) [1].