Abstract
Phaeohyphomycosis is a term used to describe a heterogenous group of cutaneous and systemic mycotic infections caused by melanized fungi. Many fungi have been reported as pathogens of this disease. The disease spectrum ranges from superficial cutaneous infections, deep cutaneous infections, to systemic infections with internal organ involvement. We report two cases of deep cutaneous phaeohyphomycosis on the foot clinically presenting as cellulitis with abscess formation. The pathogens were isolated from the lesion and both were identified as Neoscytalidium dimidiatum by their colony morphology, microscopic features, and sequences of internal transcribed spacers of ribosomal DNA. Both patients did not respond to the therapy with voriconazole and itraconazole, but improved after intravenous amphotericin B.
Keywords:
Deep fungal infection; Neoscytalidium dimidiatum; Phaeohyphomycosis; Scytalidium dimidiatum; Skin.
MeSH terms
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Abscess / diagnosis*
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Abscess / drug therapy
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Abscess / microbiology
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Abscess / pathology
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Aged, 80 and over
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Amphotericin B / administration & dosage*
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Antifungal Agents / administration & dosage*
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Ascomycota / isolation & purification*
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Cellulitis / diagnosis*
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Cellulitis / drug therapy
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Cellulitis / microbiology
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Cellulitis / pathology
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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DNA, Ribosomal Spacer / chemistry
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DNA, Ribosomal Spacer / genetics
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Dermatomycoses / diagnosis*
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Dermatomycoses / drug therapy
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Dermatomycoses / microbiology
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Dermatomycoses / pathology
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Female
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Foot / pathology
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Humans
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Male
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Microbiological Techniques
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Middle Aged
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Molecular Diagnostic Techniques
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Phaeohyphomycosis / diagnosis*
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Phaeohyphomycosis / drug therapy
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Phaeohyphomycosis / microbiology
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Phaeohyphomycosis / pathology
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Sequence Analysis, DNA
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Treatment Outcome
Substances
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Antifungal Agents
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DNA, Fungal
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DNA, Ribosomal Spacer
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Amphotericin B