Abstract
Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure-activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.
MeSH terms
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Anthracenes / chemical synthesis
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Anthracenes / chemistry*
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Anthracenes / pharmacology
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Crystallography, X-Ray
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Hydrogen Bonding
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Microscopy, Fluorescence
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Molecular Conformation
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Quaternary Ammonium Compounds / chemistry
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Structure-Activity Relationship
Substances
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Anthracenes
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Anti-Bacterial Agents
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Quaternary Ammonium Compounds
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tetrabutylammonium
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anthracene