Activation of the hippocampal AC-cAMP-PKA-CREB-BDNF signaling pathway using WTKYR in depression model rats

Yangzhi Peng; Chengchen Zhang; Yue Su; Zewen Wang; Yong Jiang

doi:10.1002/elps.201800381

Activation of the hippocampal AC-cAMP-PKA-CREB-BDNF signaling pathway using WTKYR in depression model rats

Electrophoresis. 2018 Dec 4. doi: 10.1002/elps.201800381. Online ahead of print.

Authors

Yangzhi Peng¹, Chengchen Zhang², Yue Su¹, Zewen Wang¹, Yong Jiang¹

Affiliations

¹ Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
² School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.

PMID: 30511424
DOI: 10.1002/elps.201800381

Abstract

Depression, also called "depression disorder," is characterized by a significant and persistent low mood. It has become a major refractory disease in the 21st century. In recent years, Chinese medicine has shown some important clinical value in the treatment of depression. Among them, the Warming and "Tonifying" Kidney-Yang Recipe (WTKYR) has been demonstrated to have obvious effects in the clinical treatments of depression; however, the mechanism remains unclear. This study is based on the adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cAMP response element-binding protein (CREB)-brain derived neurotrophic factor (BDNF) signaling pathway, aiming to investigate the mechanism of WTKYR. The results showed that WTKYR can upregulate AC-cAMP-PKA-CREB-BDNF in the hippocampus of depression model rats and alleviate its depressive symptoms, which may be the mechanism of WTKYR.

Keywords: Chinese medicine; Depression disorder; Hippocampus; Signaling pathway; WTKYR.

Grants and funding

National Natural Science Foundation of China