Diagnostic histochemistry in non-neoplastic skin diseases

Semin Diagn Pathol. 2018 Nov;35(6):390-398. doi: 10.1053/j.semdp.2018.10.006. Epub 2018 Oct 16.

Abstract

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. This review considers that topic.

Keywords: Connective tissue diseases; Deposition disorders; Dermatitis; Dermatosis; Histochemistry; Non-neoplastic skin disease; Panniculitis.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Histocytochemistry*
  • Humans
  • Predictive Value of Tests
  • Prognosis
  • Skin / pathology*
  • Skin Diseases / pathology*
  • Staining and Labeling