Abstract
Two new 8, 14-seco skeleton C(21) steroidal aglycones, cynanbungeigenin A (1) and cynanbungeigenin B (2), were isolated from the hydrolyzed extract of the EtOAc soluble extract of the roots of Cynanchum bungei. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D and 2D NMR spectroscopy.
MeSH terms
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Animals
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Carbon-13 Magnetic Resonance Spectroscopy
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Cynanchum / chemistry*
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Hedgehog Proteins / antagonists & inhibitors
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Mice
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NIH 3T3 Cells
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Plant Extracts / chemistry
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Plant Roots / chemistry
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Pregnanes / chemistry
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Pregnanes / isolation & purification*
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Pregnanes / pharmacology
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Proton Magnetic Resonance Spectroscopy
Substances
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Hedgehog Proteins
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Plant Extracts
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Pregnanes