Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative

Julie E Davis; Lena F Schaefer; Timothy E McAlindon; Charles B Eaton; Mary B Roberts; Ida K Haugen; Stacy E Smith; Jeffrey Duryea; Bing Lu; Jeffrey B Driban

doi:10.3899/jrheum.180240

Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative

J Rheumatol. 2019 Apr;46(4):422-428. doi: 10.3899/jrheum.180240. Epub 2018 Dec 1.

Authors

Julie E Davis^{1

2}, Lena F Schaefer^{1

2}, Timothy E McAlindon^{1

2}, Charles B Eaton^{1

2}, Mary B Roberts^{1

2}, Ida K Haugen^{1

2}, Stacy E Smith^{1

2}, Jeffrey Duryea^{1

2}, Bing Lu^{1

2}, Jeffrey B Driban^{3

4}

Affiliations

¹ From the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
² J.E. Davis, BS, Research Assistant II, Division of Rheumatology, Tufts Medical Center; L.F. Schaefer, MD, Radiology Fellow, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Rheumatology, Division of Rheumatology, Tufts Medical Center; C.B. Eaton, MD, MS, Professor of Family Medicine and Epidemiology, Director of Center for Primary Care and Prevention, Alpert Medical School of Brown University; M.B. Roberts, MSc, Statistical Programmer, Center for Primary Care and Prevention, Alpert Medical School of Brown University; I.K. Haugen, MD, PhD, Rheumatology Fellow, Department of Rheumatology, Diakonhjemmet Hospital; S.E. Smith, MD, Section Head and Weissman Distinguished Chair of Musculoskeletal Radiology, Associate Radiology Residency Program Director, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; J. Duryea, PhD, Associate Research Associate, Associate Professor of Radiology, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; B. Lu, DrPH, MD, Assistant Professor of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School; J.B. Driban, PhD, ATC, CSCS, Associate Professor, Division of Rheumatology, Tufts Medical Center.
³ From the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. jeffrey.driban@tufts.edu.
⁴ J.E. Davis, BS, Research Assistant II, Division of Rheumatology, Tufts Medical Center; L.F. Schaefer, MD, Radiology Fellow, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Rheumatology, Division of Rheumatology, Tufts Medical Center; C.B. Eaton, MD, MS, Professor of Family Medicine and Epidemiology, Director of Center for Primary Care and Prevention, Alpert Medical School of Brown University; M.B. Roberts, MSc, Statistical Programmer, Center for Primary Care and Prevention, Alpert Medical School of Brown University; I.K. Haugen, MD, PhD, Rheumatology Fellow, Department of Rheumatology, Diakonhjemmet Hospital; S.E. Smith, MD, Section Head and Weissman Distinguished Chair of Musculoskeletal Radiology, Associate Radiology Residency Program Director, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; J. Duryea, PhD, Associate Research Associate, Associate Professor of Radiology, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; B. Lu, DrPH, MD, Assistant Professor of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School; J.B. Driban, PhD, ATC, CSCS, Associate Professor, Division of Rheumatology, Tufts Medical Center. jeffrey.driban@tufts.edu.

Abstract

Objective: We aimed to determine whether hand joints develop an accelerated form of osteoarthritis (OA) and to characterize individuals who develop accelerated hand osteoarthritis (AHOA).

Methods: We evaluated 3519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand osteoarthritis (HOA). One reader scored posteroanterior radiographs of the dominant hand using a modified Kellgren-Lawrence (KL) scale and another reader scored the presence of central or marginal erosions. A third reader read images flagged for signs of diseases other than OA. We defined AHOA as ≥ 1 joints that progressed from a KL grade of 0 or 1 at baseline to KL grade 3 or 4 at 48 months.

Results: The definition of AHOA was met by 1% over 4 years: 37 hands had 1 joint affected and 1 hand had 2 joints affected. At baseline, adults who developed AHOA were more likely to have hand pain (37% vs 22%), radiographic HOA (71% vs 36%), as well as central (22% vs 7%) and marginal erosions (11% vs 2%) in other joints compared to those without AHOA. Adults with AHOA were more likely to develop new erosions over 48 months (central 35%, marginal 5%) than those without AHOA (central 5%, marginal 1%). The most common locations of accelerated OA were the second metacarpophalangeal and first carpometacarpal joint.

Conclusion: Accelerated OA can occur in the hand, especially among digits commonly used for pinching and fine motor skills.

Keywords: EPIDEMIOLOGY; HAND; OSTEOARTHRITIS.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Aged
Carpometacarpal Joints / diagnostic imaging*
Carpometacarpal Joints / pathology*
Disease Progression
Female
Follow-Up Studies
Humans
Incidence
Male
Metacarpophalangeal Joint / diagnostic imaging*
Metacarpophalangeal Joint / pathology*
Middle Aged
Osteoarthritis / diagnostic imaging*
Osteoarthritis / epidemiology*
Pain
Radiography
Risk Factors
Thumb / pathology

Abstract

Publication types

MeSH terms

Grants and funding