Structure Regulates Phage Lysis-Lysogeny Decisions

Jimmy T Trinh; Lanying Zeng

doi:10.1016/j.tim.2018.11.005

Structure Regulates Phage Lysis-Lysogeny Decisions

Trends Microbiol. 2019 Jan;27(1):3-4. doi: 10.1016/j.tim.2018.11.005. Epub 2018 Nov 28.

Authors

Jimmy T Trinh¹, Lanying Zeng²

Affiliations

¹ Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA; Center for Phage Technology, Texas A&M University, College Station, TX 77843, USA.
² Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA; Center for Phage Technology, Texas A&M University, College Station, TX 77843, USA. Electronic address: lzeng@tamu.edu.

PMID: 30502931
DOI: 10.1016/j.tim.2018.11.005

Abstract

There are many strategies by which cell fates are decided. In one intriguing case, viruses communicate via the quorum-sensing-like 'arbitrium' system to bias infection outcomes. Through elucidating the detailed molecular mechanisms of such strategies, we can better understand viral propagation and offer insights into the treatment of viral diseases.

Keywords: bacteriophage; cell fate decision; lysis–lysogeny.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Bacteriophages*
Lysogeny*
Virus Latency

Grants and funding

R01 GM107597/GM/NIGMS NIH HHS/United States