The protective effect of hyperin on LPS-induced acute lung injury in mice

Abstract

Hyperin, a flavonoid compound found in natural plants, has been reported that it have anti-inflammatory properties. However, the protective effects and mechanisms of hyperin on acute lung injury have not been reported so far. This research was designed to investigate the protective effects of hyperin on lipopolysaccharide-induced acute lung injury (ALI) in mice. The mice were stimulated with LPS in the presence or absence of hyperin and the MPO activity, lung wet/dry ratio, inflammatory cells in BALF, and cytokines, as well as NF-κB expression were assessed in lung tissue. Results showed that hyperin significantly inhibited LPS-induced histological changes, inflammatory cell infiltration, MPO activity and lung wet/dry ratio. Additionally, hyperin distinctly reduced the production of TNF-α, IL-1β and IL-6 and the activation of NF-κB signaling pathways in LPS-induced ALI in mice. In conclusion, hyperin is an effective suppressor of inflammation and may be a promising potential therapeutic reagent for ALI treatment.

Keywords: Acute lung injury (ALI); Cytokine; Hyperin; Lipopolysaccharide (LPS); Nuclear factor-kappaB (NF-κB).