The rs1805193, rs5361, and rs5355 single nucleotide polymorphisms in the E-selectin gene (SEL-E) are associated with subclinical atherosclerosis: The Genetics of Atherosclerotic Disease (GEA) Mexican study

Abstract

The aim of this study was to evaluate the association of rs1805193, rs5361, and rs5355 E-selectin gene single nucleotide polymorphisms (SNPs) with the risk of developing subclinical atherosclerosis (SA) in a group of Mexicans individuals. SNPs were determined by TaqMan genotyping assays in a group of 287 individuals with SA and 688 healthy controls. Under different models, the T allele of the 5'UTR G98 T (rs1805193) (OR = 1.71, 95%CI: 1.00-2.93, pC_Co-dominant = 0.0006, OR = 2.02, 95%CI: 1.21-3.38, pC_Dominant = 0.004, and OR = 2.14, 95%CI: 1.34-3.44, pC_Additive = 0.0015) and the C allele of the Ser128Arg A561C (rs5361) (OR = 1.60, 95%CI: 0.92-2.79, pC_Co-dominant = 0.012, OR = 1.78, 95%CI: 1.04-3.06, pC_Dominant = 0.038, and OR = 1.87, 95%CI: 1.13-3.11, pC_Additive = 0.016) polymorphisms were associated with an increased risk of development of SA. In the same way, under co-dominant model, the CT genotype of the Leu575Phe C1880T (rs5355) polymorphism was associated with an increased risk of SA as compared to CC genotype (OR = 2.34, 95%CI: 1.33-4.11, pC = 0.0035). All models were adjusted by traditional cardiovascular risk factors. In summary, this study demonstrates that the 5'UTR G98 T, Ser128Arg A561C, and Leu575Phe C1880T polymorphisms are associated with an increased risk of developing SA.

Keywords: E-selectin; Genetics; Polymorphisms; Premature CAD; Susceptibility.