Cutaneous Metastasis

John D Strickley; Alfred Bennett Jenson; Jae Yeon Jung

doi:10.1016/j.hoc.2018.08.008

Cutaneous Metastasis

Hematol Oncol Clin North Am. 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008.

Authors

John D Strickley¹, Alfred Bennett Jenson², Jae Yeon Jung³

Affiliations

¹ James Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson Street, Louisville, KY 40202, USA; Department of Dermatology, Center for Cancer Immunology and Cutaneous Biology Research Center, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
² James Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson Street, Louisville, KY 40202, USA.
³ James Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson Street, Louisville, KY 40202, USA; Division of Dermatology, University of Louisville School of Medicine, 3810 Springhurst Boulevard, Suite. 200, Louisville, KY 40241, USA; Onco-Dermatology Program, Norton Cancer Institute, 676 South Floyd Street, Suite 200, Louisville, KY 40202, USA. Electronic address: Jae.jung@nortonhealthcare.org.

PMID: 30497674
DOI: 10.1016/j.hoc.2018.08.008

Abstract

Although rare, cutaneous metastases portend a poor prognosis and are often an indicator of widespread disease. Breast cancer and melanoma are the most common types of cancer that are associated with spread to and within the skin; however, other malignancies, such as lung, colon, head and neck, and hematologic, have been described with a degree of relative frequency. A variety of clinical appearances and syndromes of cutaneous metastases are presented and described in this article. Possible treatment options, including skin-directed therapies and immunotherapies, are also discussed.

Keywords: Breast cancer; Cutaneous metastases; Dermatology; Melanoma; Metastasis; Oncology; Skin.

Publication types

Review

MeSH terms

Combined Modality Therapy / adverse effects
Combined Modality Therapy / methods
Disease Management
Humans
Neoplasm Staging
Prognosis
Skin / pathology*
Skin Neoplasms / diagnosis*
Skin Neoplasms / epidemiology
Skin Neoplasms / secondary*
Skin Neoplasms / therapy
Treatment Outcome