Abstract
Predictive models of comorbidity, dyslipidemic disorders and essential arterial hypertension, in Russian adolescents aged 12 to 18 years (mean 15.48±1.53) were formulated with consideration for biochemical (lipid profiles) and genetic parameters (carrier state of gene polymorphic variants of apolipoprotein genes ApoA1 (-75G/A and +83C/T), ApoB (Ins/Del), ApoC3 (S1/S2), and ApoE (ε2/ε3/ε4). Significant prognostic risk factors for the mentioned comorbid pathologies were lipid metabolism parameters HDL-Ch, LDL-Ch, VLDL-Ch and carrier state of the +83T allele of the ApoA1 gene and Del allele of the ApoB gene. The obtained mathematical model is characterized by high predictive accuracy: the percentage of correct classification or the rate of correct assignment of each participant to the proper group was 96.33%.
Keywords:
adolescents; apolipoproteins; dyslipidemia; genotype; hypertension.
MeSH terms
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Adolescent
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Alleles
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Apolipoprotein A-I / genetics*
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Apolipoprotein A-I / immunology
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Apolipoprotein B-100 / genetics*
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Apolipoprotein B-100 / immunology
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Apolipoprotein C-III / genetics
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Apolipoprotein C-III / immunology
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Apolipoproteins E / genetics
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Apolipoproteins E / immunology
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Carrier State
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Child
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Cholesterol, VLDL / blood
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Discriminant Analysis
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Dyslipidemias / blood
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Dyslipidemias / diagnosis*
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Dyslipidemias / genetics
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Dyslipidemias / immunology
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Essential Hypertension / blood
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Essential Hypertension / diagnosis*
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Essential Hypertension / genetics
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Essential Hypertension / immunology
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Female
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Gene Expression
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Gene Frequency
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Genetic Predisposition to Disease*
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Humans
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Male
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Models, Statistical*
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Polymorphism, Genetic*
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Prognosis
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Risk Factors
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Russia
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Triglycerides / blood
Substances
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APOA1 protein, human
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APOB protein, human
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Apolipoprotein A-I
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Apolipoprotein B-100
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Apolipoprotein C-III
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Apolipoproteins E
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Cholesterol, HDL
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Cholesterol, LDL
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Cholesterol, VLDL
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Triglycerides