• Variability of ADC measurements may be substantial across different MRI scanners and imaging sites. • DWI protocol standardization and increased awareness of frequent sources of error can help reducing the limits of expected bias. • Focusing on ADC change and normalized ADC values rather than on absolute measurements can facilitate consistent use of ADC in multi-center studies.
Keywords: Diffusion; Magnetic resonance imaging; Multi-center studies; Reproducibility of results.