Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Euro Surveill. 2018 Nov;23(47):1800617. doi: 10.2807/1560-7917.ES.2018.23.47.1800617.

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.

Keywords: FC428; Ireland; Neisseria gonorrhoeae; azithromycin; ceftriaxone; gonorrhoea; multidrug-resistant; resistance; treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / pharmacology
  • Azithromycin / therapeutic use*
  • Bacterial Proteins / genetics
  • Ceftriaxone / pharmacology
  • Ceftriaxone / therapeutic use*
  • Drug Resistance, Multiple, Bacterial
  • Gonorrhea / drug therapy*
  • Humans
  • Japan
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / genetics*
  • Neisseria gonorrhoeae / isolation & purification*
  • Whole Genome Sequencing*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Ceftriaxone
  • Azithromycin