Primary liver cancer arises from chronic liver disease, and cirrhotic liver gradually develops into dysplastic nodules that eventually form malignant tumors. In recent years, molecular biotechnology development has deepened people's understanding on the pathogenesis of liver cancer. Epigenetic modifications play a significant role in DNA methylation, non-coding RNAs, chromatin remodeling, and histone modification. This review focuses on the progress of currently implicated non-coding RNAs in the molecular pathogenesis of hepatocellular carcinoma, and its potential application in improving the diagnosis and treatment.
原发性肝癌是从慢性肝炎、肝硬化发展到非典型增生结节,最终形成恶性肿瘤的过程。近年随着分子生物学技术的发展，人们对肝癌发病机制的认识不断加深。而其中，表观遗传学改变起着至关重要的作用，其主要包括DNA甲基化、非编码RNA、染色质重构、组蛋白修饰等。现就近年在肝癌分子发病机制中非编码RNA的主要研究进展，着重阐述其在肝癌诊断与治疗中的潜在应用。.
Keywords: Carcinoma, hepatocellular; Circular RNA; Epigenetic modification; Non-coding RNA.