Interlayer expansion of 2D MoS2 nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo

Chem Commun (Camb). 2018 Dec 11;54(99):13989-13992. doi: 10.1039/c8cc08279k.

Abstract

Interlayer-expanded MoS2 (E-MoS2) nanosheets with an interlayer spacing of 0.94 nm are demonstrated to show an high photothermal conversion efficiency of ∼62%. More importantly, such biocompatible E-MoS2 nanosheets show highly improved photothermal therapy (PTT) of tumors in vitro and in vivo under near-infrared light irradiation.

MeSH terms

  • Animals
  • Biocompatible Materials
  • Combined Modality Therapy
  • Disulfides / chemistry*
  • Hep G2 Cells
  • Heterografts
  • Humans
  • Hyperthermia, Induced / methods*
  • Hyperthermia, Induced / standards
  • Infrared Rays
  • Mice
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Molybdenum / chemistry*
  • Nanostructures / chemistry*
  • Neoplasms, Experimental / therapy*
  • Phototherapy / methods*
  • Phototherapy / standards
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Near-Infrared
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Disulfides
  • Molybdenum
  • molybdenum disulfide