Triple GLP-1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer's disease

Antoni Camins; Miren Ettcheto; Oriol Busquets; Patricia R Manzine; Rubén Dario Castro-Torres; Carlos Beas-Zarate; Ester Verdaguer; Francesc X Sureda; Monica Bulló; Jordi Olloquequi; Carme Auladell; Jaume Folch

doi:10.1080/13543784.2019.1552677

Triple GLP-1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer's disease

Expert Opin Investig Drugs. 2019 Jan;28(1):93-97. doi: 10.1080/13543784.2019.1552677. Epub 2018 Dec 1.

Authors

Antoni Camins^{1

2

3}, Miren Ettcheto^{1

2

3

4}, Oriol Busquets^{1

2

3

4}, Patricia R Manzine^{1

5}, Rubén Dario Castro-Torres^{1

6

7}, Carlos Beas-Zarate⁷, Ester Verdaguer^{2

3

6}, Francesc X Sureda⁴, Monica Bulló⁴, Jordi Olloquequi⁸, Carme Auladell^{2

3

6}, Jaume Folch^{2

4}

Affiliations

¹ a Departament de Farmacologia , Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona , Barcelona , Spain.
² b Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) , Madrid , Spain.
³ c Institut de Neurociències, Universitat de Barcelona , Barcelona , Spain.
⁴ d Departament de Bioquímica i Biotecnologia , Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili , Reus , Spain.
⁵ e Department of Gerontology , Federal University of São Carlos (UFSCar) , São Carlos , Brazil.
⁶ f Departament de Biologia Cel·lular , Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona , Barcelona , Spain.
⁷ g Departamento de Biología Celular y Molecular , C.U.C.B.A., Universidad de Guadalajara y División de Neurociencias , Guadalajara , México.
⁸ h Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud , Universidad Autónoma de Chile , Talca , Chile.

PMID: 30480461
DOI: 10.1080/13543784.2019.1552677

No abstract available

Keywords: Alzheimer’s disease; glucagon; glucagon-like peptide; glucose-dependent insulinotropic peptide; type 2 diabetes.

Publication types

Editorial

MeSH terms

Alzheimer Disease / drug therapy*
Alzheimer Disease / physiopathology
Animals
Drug Development / methods*
Glucagon-Like Peptide 1 / agonists
Humans
Molecular Targeted Therapy*
Receptors, Gastrointestinal Hormone / agonists
Receptors, Glucagon / agonists

Substances

Receptors, Gastrointestinal Hormone
Receptors, Glucagon
Glucagon-Like Peptide 1
gastric inhibitory polypeptide receptor