Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles

Chem Commun (Camb). 2018 Dec 11;54(99):13973-13976. doi: 10.1039/c8cc08355j.

Abstract

Nanoceria is considered as a potent antioxidant (free radical scavenger) and its enzymatic activity is reported to be a function of the oxidation state of surface cerium ions. Here we demonstrate phosphine ligand-dependent enzymatic activity of nanoceria irrespective of its as-synthesized oxidation state.

MeSH terms

  • Catalase / metabolism*
  • Cerium / pharmacology*
  • Free Radical Scavengers / pharmacology*
  • Ligands
  • Metal Nanoparticles*
  • Molecular Mimicry*
  • Oxidation-Reduction
  • Phosphines / chemistry
  • Phosphines / metabolism*
  • Phosphites / chemistry
  • Reactive Oxygen Species / metabolism*
  • Spectrum Analysis / methods
  • Superoxide Dismutase / metabolism*

Substances

  • Free Radical Scavengers
  • Ligands
  • Phosphines
  • Phosphites
  • Reactive Oxygen Species
  • tris(2,4,6-trimethoxyphenyl)phosphine
  • Cerium
  • ceric oxide
  • triethyl phosphite
  • Catalase
  • Superoxide Dismutase
  • phosphine