DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38

Maud de Dieuleveult; Benoit Miotto

doi:10.1177/2516865718811117

DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38

Epigenet Insights. 2018 Nov 19:11:2516865718811117. doi: 10.1177/2516865718811117. eCollection 2018.

Authors

Maud de Dieuleveult^{1

2

3}, Benoit Miotto^{1

2

3}

Affiliations

¹ Institut Cochin, INSERM U1016, Paris, France.
² CNRS UMR8104, Paris, France.
³ Department of Development, Reproduction and Cancer, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Abstract

DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation-sensitive transcription factors in mammalian cells.

Keywords: DNA methylation; DNA replication; ZBTB38; cancer; gene expression.

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